Therapeutic compositions for treating or preventing urinary tract infections in warm-blooded animals, including humans, contains a combination of trimethoprim or pharmaceutically salts thereof and cranberry extract in an effective amount to prevent, reduce or eliminate symptoms associated with the infection, and a pharmaceutically acceptable carrier. The resulting therapeutic composition can be in a form of a solution such as a beverage drink, or a solid such as a powder drink mix for preparing a beverage drink through the addition of a liquid.