The present invention relates to nucleotides encoding for the production
of novel regulatory proteins for Nox enzymes involved in generation of
reactive oxygen intermediates that affect cell division. The present
invention also provides vectors containing these nucleotides, cells
transfected with these vectors, antibodies raised against these novel
proteins, kits for detection, localization and measurement of these
nucleotides and proteins, and methods to determine the activity of drugs
to affect the biological activity of the regulatory proteins of the
present invention.