An electrochromic window includes a first transparent, e.g., plastic, substrate having a first primer over at least a portion thereof and a first electrically conductive coating over at least a portion of the first primer. A second transparent plastic substrate has a second primer over at least a portion thereof and a second electrically conductive coating over at least a portion of the second primer. The first primer has a coefficient of expansion less than the coefficient of expansion of the first plastic substrate, and the second primer has a coefficient of expansion less than the coefficient of expansion of the second plastic substrate. An electrochromic medium is located between the first and second electrically conductive coatings. At least one of the first and second electrically conductive coatings has a metal layer located between first and second metal oxide layers.

 
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> Methods for modulating IKK.alpha. activity

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