A motor control system capable of securing stability and rapidity of motion even in a machine where the stability varies in accordance with a position of a driven member. The driven member and a motor for driving the driven member are operatively connected through a transmission mechanism including a nonlinear element such that a rate of change of the position of the driven member with respect to the position of the motor varies in dependence on the position of the motor. Optimum values of multiplier factors of operation constants with respect to the position of the driven member or the rotational position of the motor for the position control and the velocity control are stored in a data table. The values of the multiplier factors of the operation constants for a present position of the driven member or a present position of the motor are determined using the data table and the determined values of the multiplier factors are multiplied by reference operation constants to update the operation constants. The position and/or velocity control processing is performed using the updated optimum operation constants in accordance with the present position of the driven member or the present rotational position of the motor.