A biocompatible bonding material is applied as an intermediary to attach prosthesis to boney tissue. The bonding material has the strength and rapid setting characteristics of PMMA cement, and is incorporated by the supporting bone as the boney ingrowth and osteogenic growth processes take place. In one embodiment, the bonding material is comprised of calcium phosphate polymer that provides immediate hardening and bonding, thereby locking the prosthesis to the bone. The biologic bond allows for bone in-growth over a period of weeks providing long term fixation. The immediate bonding can eliminate the early loosening that commonly occurred with uncemented joint replacements.