The invention relates to processes for the preparation of highly
concentrated, liquid formulations comprising at least one anti-EGFR
antibody and/or one of its variants and/or fragments, in particular
monoclonal antibodies against the EGF receptor, particularly preferably
of Mab C225 (cetuximab) and Mab h425 (EMD 72000), by ultrafiltration. The
invention furthermore relates to highly concentrated, liquid formulations
of anti-EGFR antibodies, in particular of monoclonal antibodies against
the EGF receptor, particularly preferably Mab C225 (cetuximab) and Mab
h425 (EMD 72000) and/or variants and/or fragments thereof, characterised
in that the highly concentrated, liquid formulations have a content of
anti-EGFR antibodies of 10-250, preferably 50-180 mg/ml, particularly
preferably of 100-150 mg/ml, and to the use thereof.