The invention relates to a folding machine for the graphics industry. The machine has a folder, at least one pair of blade shafts following the folder, and a separate roll frame that supports the pair of blade shafts. In order to be able to perform changeover operations on the pair of blade shafts as ergonomically as possible without partial dismantling of the folding machine, the folding machine is equipped with a guide for the roll frame and with an actuating device (e.g., tooth rack, pinion, crank) for displacing the roll frame along the guide.