The present invention relates to systems and methods that remove echo from a signal via a novel echo cancellation technique that supports arbitrary playback sampling rates. The novel echo cancellation technique transforms a playback signal to a frequency domain representation and converts its sampling rate to a sampling rate of a frequency domain transformed received signal for the appropriate number of frequency bins. This conversion is achieved via an exact or interpolated approached. The re-sampled playback signal transform is then utilized in connection with the received signal transform to remove echo associated with the playback signal from the received signal.