Devices and methods which generate reduced pressures to treat biological external tissue using at least one energy source are disclosed. The energy source may be incoherent light, coherent light, a radio frequency, ultrasound, a laser, and/or any other type of energy that can be applied through the device. The energy source may be a single or pulsed application of energy. The features of various embodiments of the device include the generation of positive pressure and/or negative pressure through one or more pressure conduits, the application of an object within a recess of the device, and measurements through various sensors on the device. The device may be a handheld device or an add-on to existing devices in some embodiments.