A technique is provided for visualizing a volume of interest, such as may be acquired by a tomosynthesis imaging system. The technique provides for the use of one or more weighting functions, such as depth-dependent weighting functions, in the determination of pixel values in a volume rendering. The weighting functions may modify, for example, an intensity determination for a pixel, either directly or by modifying other contributing functions, such as for determining occlusion effects. The volume rendering may then be displayed for review by a technologist or clinician.