Compounds of Formula I are provided, in which variables are as described
herein: ##STR00001## Such compounds may be used to modulate MCH binding
to MCH receptors in vivo or in vitro, and are particularly useful in the
treatment of a variety of metabolic, feeding and sexual disorders in
humans, domesticated companion animals and livestock animals.
Pharmaceutical compositions and methods for treating such disorders are
provided, as are methods for using such ligands for detecting MCH
receptors (e.g., receptor localization studies).