The present invention relates to isolated polynucleotide comprising a
sequence selected from the group consisting of: (a) a polynucleotide
comprising a sequence encoding the polypeptide SEQ ID NO:3 or a
biologically active or immunogenic fragment thereof; (b) a polynucleotide
comprising a sequence encoding the polypeptide SEQ ID NO:4 or a
biologically active or immunogenic fragment thereof; (c) a polynucleotide
which hybridises to a polynucleotide having a sequence complementary to
that of the polynucleotide (a) and (b); and (d) a RNA equivalent to the
sequences (a) to (c). The invention also provides methods of treatment
and diagnosis of diseases associate with the repression or decreased
expression of functional PRAP. In some instances, methods of treatment
associated with the stimulation of cell proliferation is also provided,
in particular, for the treatment of wounds.