The present invention is directed to a carbamazepine-cyclodextrin
inclusion complex useful for the parenteral administration of
carbamazepine. The carbamazepine-cyclodextrin inclusion complex is
prepared by the admixture of a modified cyclodextrin and carbamazepine in
a physiologically acceptable fluid. Modified cyclodextrins include
2-hydroxypropyl-beta-cyclodextrin and sulfoalkyl cyclodextrins. More
particularly, the sulfoalkyl cyclodextrins are those described and
disclosed in U.S. Pat. Nos. 5,134,127 and 5,376,645. A physiologically
acceptable fluid includes sterile isotonic water, Ringer's lactate, D5W
(5% dextrose in water), physiological saline, and similar fluids suitable
for parenteral administration.