A system and method are described for processing medical knowledge. The system comprises a database, a rendering engine and a feedback engine. The database may include medical knowledge sources, wherein an ontology specifies how the medical knowledge sources apply to specific disease conditions and patient populations. The rendering engine may convert medical knowledge obtained from the medical knowledge sources to a format suitable for a presentation to a patient on a selected patient device. The feedback engine may receive feedback from a plurality of patients and to provide feedback data to the database and the knowledge sources.