A conjugate of formula A-L-P, in which: A represents a
glycosylated/galactosylated peptide that binds to a cell-surface
receptor, L represents a bifunctional linker, which does not comprise a
naturally occurring amino acid and is covalently bonded to A and P in a
regiospecific manner, and P represents a monomer, homopolymer or
heteropolymer comprising at least one nucleotide or an analogue thereof,
which inhibits the intracellular biosynthesis of nucleotides or nucleic
acids in a sequence-independent manner, wherein either or both of the
covalent bond between A and L and the covalent bond between L and P can
be cleaved intracellularly; a composition comprising such a conjugate;
and a method of inhibiting abnormal cellular proliferation in a mammal;
and a method of inhibiting replication of a virus in a mammal.