The invention relates to a method for producing hollow fiber membranes having an interior separation layer, said separation layer being produced according to the phase interface polymerization method. According to the inventive method, once the hollow fibers are produced, a) their interior is flushed with an amine solution, b) said amine solution is replaced by an agent that is inert relative to the amine solution, c) and the inert agent in the interior is displaced by an acid chloride solution.