Compounds are provided which are antagonists of the calcium sensing
receptor, and have the general formula ##STR00001## wherein m is 0, 1,
2, 3 or 4; each X is independently selected from the group consisting of
hydrogen, halo, cyano, nitro, OCF.sub.3, hydroxy, amino, carboxyl, alkyl,
alkenyl, alkynyl, cycloalkyl, cycloheteroalkyl, haloalkyl, alkoxy,
alkoxycarbonylalkyl, hydroxycarbonylalkyl, aryl, arylalkyl, heteroaryl,
heteroarylalkyl, cycloalkylalkyl, R.sup.1O, R.sup.1R.sup.2N, R.sup.1OCO,
R.sup.1CO, R.sup.1R.sup.2NCO, R.sup.1R.sup.2NCONR.sup.2a,
R.sup.1OCONR.sup.2a, R.sup.1CONR.sup.2a, R.sup.1S, R.sup.1SO,
R.sup.1SO.sub.2, R.sup.1R.sup.2NSO.sub.2,
R.sup.1R.sup.2NSO.sub.2NR.sup.2a, and R.sup.1SO.sub.2NR.sup.2a; R.sup.1
is alkyl, alkenyl, alkynyl, cycloalkyl, cycloheteroalkyl, aryl,
heteroaryl, arylalkyl, or heteroarylalkyl; R.sup.2 and R.sup.2a are the
same or different and are independently selected from hydrogen, alkyl,
alkenyl, alkynyl, cycloalkyl, cycloheteroalkyl, aryl, heteroaryl,
arylalkyl, or heteroarylalkyl; n is 1, 2, or 3; W is O or H,R.sup.3;
R.sup.3 is hydrogen or hydroxyl; Ar is a substituted or unsubstituted
aryl group or a substituted or unsubstituted heteroaryl group; Q is
hydrogen, F, or hydroxyl. In addition, a method for using these
compounds to treat diseases associated with abnormal or mineral
homeostasis is also provided.