A norovirus-permissive cell culture infected with a norovirus, and methods
of culturing a norovirus, are disclosed. Norovirus-permissive cells
include dendritic cell-lineage cells, and macrophage-lineage cells, such
as dendritic cells, and macrophages having a deficiency in a cellular
anti-viral pathway such as a STAT-1-dependent pathway, an interferon
receptor-dependent pathway, or a PKR-dependent pathway. Also disclosed
are methods of screening anti-viral compounds against
norovirus-permissive cells infected with norovirus, and norovirus adapted
to grow in fibroblasts as well as macrophages that are not deficient in a
cellular anti-viral pathway. Methods of making a norovirus vaccine are
also disclosed.