Generation of multiple neurostimulation programs for delivery of neurostimulation therapy to a patient involves generation of a base program and one or more patient condition algorithms. The base program is modified according to specific algorithms associated with the patient condition algorithms to generate multiple neurostimulation programs. The patient condition algorithms specify modifications to parameters in the base program to generate programs that are better tailored to a particular condition. The base program serves as a starting point for the generation of multiple neurostimulation programs tailored to patient activities. The patient condition algorithms may correspond to different patient conditions or activities, for example, such as sitting, standing, sleeping, working, walking, running, exercising, or the like. The multiple programs can be loaded into an implanted neurostimulation device or patient programmer.