A system and methods for performing calorimetric testing which includes a micro resonator that supports a plurality of whispering gallery mode resonant frequencies, a first waveguide that receives light and evanescently couples whispering gallery mode resonant frequencies from the first waveguide into the micro resonator, and a second waveguide evanescently coupled to the micro resonator such that a portion of the whispering gallery mode resonant frequencies are coupled out of the micro resonator and into the second waveguide. The system can also include a light source for providing a multitude of optical resonances and a reader for analyzing the resonances received from the second waveguide.