The present invention relates to treatment of joint or muscle pain and, in particular, combinations of ingredients for such treatment. The invention provides a composition, which includes the following components: emu oil, a salicylate analgesic agent, devil's claw, and ginger. The components are present in the composition in an amount sufficient to alleviate joint or muscle pain in a mammal in need thereof. A composition having essentially emu oil, a salicylate analgesic agent, devil's claw and ginger is also provided. The invention further provides a method for alleviating joint or muscle pain in a mammal. The method includes administering topically to the mammal the composition of the present invention.