A printing system and method is provided including a printer having an print marking means for printing a printer-ready document, including transferring or applying an image associated with the printer-ready document to a substrate; and a processor assembly in operative communication with the printer. The processor assembly executes application software for receiving a print job request including the printer-ready document. The processor assembly includes a module for accessing print defect data indicating location and color separation information on the print marking means which corresponds to a detected print defect; and a module for modifying the printing in accordance with the print defect data for minimizing visibility of the detected print defect in the printer-ready document once printed.