The present invention is directed to extracts of cranberries (Vaccinium macrocarpon) comprising either mixed flavonols that are substantially free of anthocyanins and proanthocyanidins or a purified cranberry flavonol compound, including myricetin-3-.beta.-xylopyranoside, quercetin-3-.beta.-glucoside, quercetin-3-.alpha.-arabinopyranoside, 3'-methoxyquercetin-3-.alpha.-xylopyranoside, quercetin-3-O-(6''-p-coumaroyl)-.beta.-galactoside, and quercetin-3-O-(6''-benzoyl)-.beta.-galactoside. The present invention also embodies the use of those extracts, as well as extracts comprising the cranberry flavonol compound quercetin-3-.alpha.-arabinofuranoside, for the treatment of inflammatory disorders. Pharmaceutical, food, dietary supplement, and cosmetic compositions utilizing the extracts or compounds of the present invention are also recited.