Systems, processes and apparatus are described through which non-destructive imaging is achieved, including a process for variable binning of detector elements. The process includes accepting input data indicative of image quality goals and descriptors of an imaging task, as well as parameters characterizing a test subject, relative to non-destructive imaging of an internal portion of the test subject and determining when the non-destructive imaging system is capable of achieving the image quality goals using binning of more than four pixels.