The invention is an automated multiple-purpose, integrated laboratory
system comprising interchangeable modular elements for the construction
and measurement of biological assays. The functions of the modular
elements may include multiwell platform handling, chemical reagent or
cell management, volumetric transfer of liquids for assay construction or
for recovery of reaction products for analysis, incubation under
controlled environmental conditions, measurement of spectrometric signals
originating from the assays, processing and analysis of the resulting
spectrometric data, and other functions. The modular elements are
arranged around a number of robotic elements that deliver plates to
different modular elements, transfer plates to groups of modules served
by a different robotic element, or other actions necessary in plate
handling. Liquid transfer to and from multiwell platforms, necessary for
assay construction or for the initiation of physiological events in
cells, is partitioned among different modules specialized for
transferring nanoliter or smaller volume quantities of chemical
concentrates, or microliter quantities of assay reagents, cells, media
and other assay constituents. Applications of this invention include the
quantitation and analysis of the expression of multiple genes in cells,
measurement of multi-gene expression kinetics, analysis of activation or
suppression of multiple signal transduction pathways, screening chemical
compounds for modulatory effects on multi-gene expression or on signal
transduction pathways or on other biochemical networks of cells, or other
analytical biological or biochemical assays.