Compounds are provided having the formula: ##STR00001## wherein variables R.sup.0, R.sup.1, R.sup.2, R.sup.3, R.sup.4, Q, L and subscript n are as described herein. The subject compounds are useful for treatment of infammatory and immune conditions and diseases. Compositions and methods of treatment using the subject compounds are also provided. For example, the subject methods are useful for treatment of inflammatory and immune disorders and disease such as multiple sclerosis, rheumatoid arthritis, psoriasis, and inflammatory bowel disease.

 
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> Methods of treatment using specific binding agents of human angiopoietin-2

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