In an amplifier circuit with reduced power-off transients, an amplifier is provided for receiving an input signal and a reference signal to generate an output signal therefrom when it is enabled, and the amplifier is disabled when the supply voltage to the amplifier drops down to a threshold or to a level higher than the reference signal a threshold. The output stage transistor of the amplifier is applied with a body voltage to suppress the body diode parasitic to the output stage transistor to be forward-biased.