A syringe interface or adapter includes a first retaining member that pivots about an axis generally perpendicular to and offset from the axis of an injector piston when the syringe interface is attached to the injector. The first retaining member pivots in a rearward direction to engage a portion of the syringe flange. The syringe interface further includes a second retaining member slideably positioned within a passage in the syringe interface to slide in a direction generally perpendicular to the axis of the piston when the syringe interface is attached to the injector to engage a portion of the syringe flange. The first retaining member and the second retaining member preferably cooperate to engage the syringe flange around the entire perimeter of the syringe flange. The first retaining member is preferably biased toward an open position. The syringe interface can also include a rear portion having an attachment mechanism to attach the syringe interface to the injector.