Methods and apparatus optimized for compiling instructions in a data processor are disclosed. In one aspect, a method of address calculation is disclosed, comprising operating a compiler to generate at least one instruction; canonicalizing the address calculation in a plurality of different approaches: in one exemplary embodiment, the first approach comprises canonicalizing the "regular" 32-bit instruction addressing modes, and the second for the "compressed" 16-bit instruction addressing modes. In another aspect, a plurality of functions (up to and including all available functions) are called indirectly to allow addresses to be placed in a constant pool. Improved methods for instruction selection, register allocation and spilling, and instruction compression are provided. An improved SoC integrated circuit device having an optimized 32-bit/16-bit processor core implementing at least one of the foregoing improvements is also disclosed.

 
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> X-ray crystal structures of functional ribosome complexes containing transfer RNA and model messenger RNAs and methods of use

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