A pedaling exerciser with a twister device has a base, a twister device mounted on the base, a pedaling assembly combined with the twister device, and an optional shell covering crank drums of the pedaling assembly. The twister device is composed of an intermediate plate and a rotating plate mounted. The intermediate plate is secured on a central shaft of the base and has multiple balls rotatably mounted thereon. The rotating plate rotatably mounted on the intermediate plate and has a bearing attached thereon around the central shaft to keep the rotating plate stable during rotation. Moreover, the rotating plate has a pin assembly movably engaged the intermediate plate to lock the twister device. By having the twister device, the pedaling exerciser selectively works pedaling and twisting functions at the same time.