A human interface and input system is implemented on an input accelerator device to remotely operate hand-held host electronic devices such as cellular phones, PDA's, pocket PC's, and smart phone's. The input accelerator device can control some or all functions of the host device to eliminate the need to directly interface with the host device. The input accelerator device may be configured to optimize a biomechanical effect of a human user's opposing thumb and fingers by including, on one surface, one or more software configurable input elements manipulatable by the user's thumb(s) or finger, and, on another surface, one or more software configurable selection elements manipulatable by a user's finger(s). The input accelerator device can be a hybrid device combining a wireless headset with the device control features.