A method for the manufacture of Lovastatin of formula (I) is disclosed.
The method comprises of: A. lactonisation of Mevinolinic acid (II) and
isolation of impure Lovastatin (I), B. purification of impure Lovastatin
(I), C. optionally, repurification of pure Lovastatin (I) from a mixture
of alumina and a water miscible solvent.