The invention disclosed herein describes a novel therapeutic target for
motoneuron diseases (altered dynamics of microtubules in neurons); a
method for measuring the state of activity of this therapeutic target in
subjects with established, incipient, or potential motoneuron disease;
the discovery of drug agents that modulate neuronal microtubule dynamics
in living subjects with motoneuron diseases; the discovery that
administration of such agents, alone or in combinations, can provide
marked neuroprotective therapy for living subjects with motoneuron
diseases including delay in symptoms and prolongation of survival; and
the discovery that monitoring of neuronal microtubule dynamics in
subjects with motoneuron diseases, in response to therapeutic
interventions, allows diagnostic monitoring for optimization of
therapeutic regimen and strategy for individual subjects or for drug
trials.