An endoscopic instrument to be used with an endoscope. The instrument includes an elongated tube having a distal end and a proximal end, an end effector attached to the distal end of the elongated tube, and a handle attached to the proximal end. The handle includes a mechanism for attaching the instrument to a first vacuum source. The handle further includes a second vacuum source integral with the handle for amplifying the first vacuum source, whereby the first and second vacuum sources combine to operate the end effector.