Analogues of the peptide PYY (1-36) are described in which the tertiary
structure of the peptide is preserved and stabilised particularly to
enhance binding and activation of the Y2 receptor by the use of cross
links or rigid bends in the peptide to constrain conformationally the
positions of the N-terminal part of the peptide sequence and amino acid
34. The analogues are useful in the control of food intake.