Provided, among other things, is a method of treating an indication of mucosal or adjacent tissue comprising periodically applying to mucosa at or adjacent to disease affected tissue a delivery device comprising a backing layer and an adhesive reservoir comprising an effective amount of appropriate composition of plant extract(s) comprising extract of Sambucus nigra, wherein the adhesive reservoir comprises 30 to 70 polymer by weight, of which a major portion comprises polyacrylic polymer, wherein the delivery device is flexible and tissue conforming.