An asafetida extract in the preparation of medicine for abstinence of drugs. A method for abstinence of drugs, which comprises administering a therapeutically effective amount of asafetida extract to subjects. The asafetida extract may be extracted from factice resin of Ferula sinkiangensis K. M. Shen or Ferula fukanensis K.M. Shen, and consists essentially of .alpha.-pinene, .alpha.-terpinene, 2-borneol, terpin-4-ol, D-fenchyl alcohol, pinocarveol, .beta.-ocimene A, .beta.-ocimene B, di-sec-butyl disulfide, sec-butyl-trans-1-butenyl disulfide, sec-butyl-cis-propenyl disulfide, sec-butyl-cis-1-butenyl disulfide, sec-butyl-trans-2-butenyl disulfide and thio-sec-butyl-trans-methylethenyl disulfide. The asafetida extract may also be extracted from factice resin of F. assafoetida L from Iran and Afghanistan and the like, and consists essentially of .alpha.-pinene, 2-borneol, terpin-4-ol, D-fenchyl alcohol, pinocarveol, dimethyl disulfide, dimethyl trisulfide, methylpropenyl disulfide, 2,2-dimethylthiopropane, 1,2-diethylthiopropane, N,N-dimethylthioformamide and propenylbutyl disulfide. The medicine for abstinence of drugs prepared with asafetida extract is suitable for the use in the abstinence treatment of subjects addicted to opioid, morphine, marijuana, diamorphine and the like.