The invention provides 15.beta.-substituted steroidal compounds having selective estrogen receptor activity according to Formula (I) wherein, R.sup.1 is H, C.sub.1-5 alkyl, C.sub.1-12 acyl, di-(C.sub.1-5 alkyl)aminocarbonyl, (C.sub.1-5alkyl)oxycarbonyl or sulfamoyl, R.sup.2 is H, C.sub.1-3alkyl, C.sub.2-3alkenyl or C.sub.2-3alkynyl, each of which may be optionally substituted with a halogen, R.sup.3 is C.sub.1-2alkyl, ethenyl or ethynyl, each of which may be optionally substituted with a halogen, and R.sup.4 is H or C.sub.1-12 acyl.