Disclosed herein are sequences, molecules and methods used to suppress the
expression of HD genes encoding for huntingtin protein in primates
including Macaca mulatta and Homo sapiens. These sequences, molecules and
methods aid in the study of the pathogenesis of HD and can also provide a
treatment for this disease by reducing HD mRNA without causing death,
locomotor impairment or cellular alterations of the Macaca mulatta and
Homo sapiens.