This invention provides a novel transformed cell useful in constructing an
anti-aging agent screening system, a screening method which uses the same
and an anti-aging agent, and it relates to a transformed cell in which a
gene coding for (a) a protein capable of phosphorylating p38 protein, or
(b) p38 protein, a mutant of p38 protein, a kinase domain of p38 protein,
a kinase domain of p38 protein mutant or a fusion protein containing them
is transformed into a normal cell, a screening method which uses this
transformed cell and an anti-aging agent which uses a compound obtained
by the screening method as the active ingredient.