A medical device, e.g., a stent, is provided with different coatings on different surfaces, or with a coating on only one of the inside or outside surface. In accordance with certain embodiments, two different stent members are provided, one to fit inside of the other. When the two stent members are separate, both stent members are coated, each with a different composition, or only one stent member is coated. Then, one stent member is placed inside the other to form the final stent. The resulting stent has one composition on its outside surface and a different composition on its inside surface, or coating only on either the inside or outside surface.