Devices and methods for achieving weight loss in obese and morbidly obese patients are disclosed. The invention combines a gastric and/or small bowel bypass (in which ingested food bypasses the stomach and, optionally, at least a portion of the small bowel) and a satiety device in the form of one or more expandable chambers, that tend to induce a feeling of satiety after the patient has consumed a relatively small amount of food. This combination of gastric and/or small bowel bypass and satiety structure may be delivered and removed using minimally invasive procedures such as an endoscope. In some instances, the gastric and/or small bowel bypass device itself can form the satiety structure. In other devices, the gastric bypass may be independent of the satiety structure (which may be provided as one or more expandable chambers).