The present invention is directed to a compound of Formula (I) wherein
Cy.sup.1, Cy.sup.2, L.sup.1, L.sup.2, and R.sup.1 are as defined herein,
a pharmaceutical composition comprising a pharmaceutically effective
amount of one or more compounds according to Formula (I) in admixture
with a pharmaceutically acceptable carrier, and a method of treating a
patient suffering from a PGD2-mediated disorder including, but not
limited to, allergic disease (such as allergic rhinitis, allergic
conjunctivitis, atopic dermatitis, bronchial asthma and food allergy),
systemic mastocytosis, disorders accompanied by systemic mast cell
activation, anaphylaxis shock, bronchoconstriction, bronchitis,
urticaria, eczema, diseases accompanied by itch (such as atopic
dermatitis and urticaria), diseases (such as cataract, retinal
detachment, inflammation, infection and sleeping disorders) which is
generated secondarily as a result of behavior accompanied by itch (such
as scratching and beating), inflammation, chronic obstructive pulmonary
diseases, ischemic reperfusion injury, cerebrovascular accident, chronic
rheumatoid arthritis, pleurisy, ulcerative colitis and the like by
administering to said patient a pharmaceutically effective amount of a
compound according to Formula (I).