The present invention provides nucleoside aryl phosphoramidates which are
precursors to inhibitors of RNA-dependent RNA viral polymerase. These
compounds are precursors to inhibitors of RNA-dependent RNA viral
replication and are useful for the treatment of RNA-dependent RNA viral
infection. They are particularly useful as precursors to inhibitors of
hepatitis C virus (HCV) NS5B polymerase, as precursors to inhibitors of
HCV replication, and/or for the treatment of hepatitis C infection. The
invention also describes pharmaceutical compositions containing such
nucleoside aryl phosphoramidates alone or in combination with other
agents active against RNA-dependent RNA viral infection, in particular
HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA
polymerase, inhibiting RNA-dependent RNA viral replication, and/or
treating RNA-dependent RNA viral infection with the nucleoside aryl
phosphoramidates of the present invention.