The invention relates to methods of applying energy to various body portions to produce a therapeutic response. According to embodiments, the applied energy is ultrasound and may be delivered by an ultrasound focusing device deployed in the body, for example, by using an endoscope. The energy may be used to effect a variety of therapeutic responses, including ablating lesions in the gall bladder, treating gastrointestinal reflux disease, or treating fecal incontinence.