A device for packaging and dispensing a substance including a drive mechanism having a first part and a second part capable of rotating around an axis relative to the first part to dispense a substance. The first or second part having an element which is axially stationary along the axis relative to the other of the first or second part. The device further including a base part in which at least part of the second part is received and an anti-rotation element secured to the second part. The anti-rotational device adapted for cooperating with the base part in such a manner as to enable the drive mechanism to move axially along the axis relative to the base part while enabling the second part to be substantially stationary in rotation relative to the base part. An elastically deformable member is included for exerting a force against the drive mechanism.