A method for manufacturing multiple label-seals is described, wherein a self-adhesive material having a tape, an intermediate adhesive layer, and a liner coupled to the tape via the adhesive layer is fed, at least one first printing layer is printed successively onto a tape region of the tape to form each corresponding label, at least one unprinted tape region of the tape adjacent to the printed tape region is further cut and extracted, at least one heat-shrinkable plastic film is further mounted onto the printed tape region of the tape to form each corresponding seal, and the label-seals are finally cut and separated on the liner by removing skeleton portions of the printed tape region and the heat-shrinkable plastic film adjacent to the label-seals.