According to the invention, there is provided a novel soybean variety designated XB22H05. This invention thus relates to the seeds of soybean variety XB22H05, to the plants of soybean XB22H05 to plant parts of soybean variety XB22H05 and to methods for producing a soybean plant produced by crossing plants of the soybean variety XB22H05 with another soybean plant, using XB22H05 as either the male or the female parent.