A method of attaching a knotting element to a suturing device including the steps of providing an adapter for insertion into a body, the adapter having a proximal end and an open distal end. Providing a knot tying element for tying suture together. Releasably attaching the distal end of the adapter to the knot tying element by inserting a proximal end of the knot tying element into the open distal end of the adapter and thereafter rotating the knot tying device with respect to the adapter.

 
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> Animal model for type II diabetes mellitus and Syndrome X and methods and uses thereof

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