A system and method for providing diagnosis and monitoring of myocardial ischemia for use in automated patient care is described. At least one recorded physiological measure is compared to at least one other recorded physiological measure on a substantially regular basis to quantify a change in patient pathophysiological status for equivalent patient information. An absence, an onset, a progression, a regression, and a status quo of myocardial ischemia is evaluated dependent upon the change in patient pathophysiological status.